Tlr9

Predicted to enable several functions, including protein homodimerization activity; siRNA binding activity; and unmethylated CpG binding activity. Involved in several processes, including positive regulation of intestinal epithelial cell development; positive regulation of macromolecule biosynthetic process; and regulation of defense response. Acts upstream of or within several processes, including cellular response to chloroquine; negative regulation of ERK1 and ERK2 cascade; and regulation of macromolecule metabolic process. Located in cytoplasmic vesicle; endoplasmic reticulum; and plasma membrane. Is expressed in brain and intestine. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in several diseases, including allergic bronchopulmonary aspergillosis; cystic fibrosis; glomerulonephritis (multiple); hepatitis B; and lung disease (multiple). Orthologous to human TLR9 (toll like receptor 9). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tlr9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Tlr9 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Tlr9 gene, providing context for its role in the cell.