Rxfp1 Gene Summary [Mouse]
Enables hormone binding activity. Acts upstream of or within several processes, including lung connective tissue development; myofibroblast differentiation; and nipple morphogenesis. Predicted to be active in plasma membrane. Is expressed in brain; mandibular process; metanephros; and oral region epithelium. Orthologous to human RXFP1 (relaxin family peptide receptor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rxfp1 |
| Official Name | relaxin/insulin-like family peptide receptor 1 [Source:MGI Symbol;Acc:MGI:2682211] |
| Ensembl ID | ENSMUSG00000034009 |
| Bio databases IDs | |
| Aliases | relaxin/insulin-like family peptide receptor 1 |
| Synonyms | Gm1018, LGR7, relaxin family peptide receptor 1, relaxin/insulin-like family peptide receptor 1, RXFPR1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rxfp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Leucine-rich repeats, outliers
- Leucine-rich repeats, typical (most populated) subfamily
- hormone binding
- protein phosphatase 1 regulatory subunit 42
- ectodomain
- Leucine rich repeat
- calcium binding loop
- protein binding
- Leucine Rich repeats (2 copies)
- seven-transmembrane G protein-coupled receptor superfamily
- transmembrane domain
- LDLa
- extracellular loop
- 7 transmembrane receptor (rhodopsin family)
Pathways
Biological processes and signaling networks where the Rxfp1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- fibrosis
- acute lymphoblastic leukemia
- systemic sclerosis
- congestive heart failure
- pulmonary fibrosis
- cryptorchidism
- azoospermia
regulates
- cyclic AMP
- ACTA2
- synthetic promoter
- Seap reporter gene
- ADCY
role in cell
- expression in
- migration
- differentiation
- organization
- chemotaxis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- cellular membrane
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rxfp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- extracellular matrix organization
- lung connective tissue development
- nipple morphogenesis
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- activation of adenylate cyclase activity
- hormone-mediated signaling pathway
- parturition
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- G-protein coupled peptide receptor activity
- protein binding
- metal ion binding
- hormone binding