Prtg Gene Summary [Mouse]
Enables identical protein binding activity and signaling receptor activity. Acts upstream of or within negative regulation of neurogenesis. Located in plasma membrane. Is expressed in several structures, including embryo ectoderm; eye; mandible primordium; primitive streak; and somite. Orthologous to human PRTG (protogenin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prtg |
| Official Name | protogenin [Source:MGI Symbol;Acc:MGI:2444710] |
| Ensembl ID | ENSMUSG00000036030 |
| Bio databases IDs | |
| Aliases | protogenin |
| Synonyms | A230098A12Rik, IGDCC5, LOC145786, protogenin, RGD1307157 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prtg often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signaling receptor activity
- FN3
- immunoglobulin domain
- ectodomain
- Immunoglobulin like
- Purple acid Phosphatase, N-terminal domain
- Immunoglobulin I-set domain
- Fibronectin type 3 domain
- identical protein binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- insulin resistance
- prostatic carcinoma
- prostate cancer
- yolk sac neoplasm
- germ cell neoplasia
- testicular carcinoma
- testicular cancer
- blindness
- tinnitus
regulated by
role in cell
- differentiation
- degranulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prtg gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of neurogenesis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- signaling receptor activity