Mnat1 Gene Summary [Mouse]
Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity and zinc ion binding activity. Acts upstream of or within several processes, including adult heart development; response to calcium ion; and ventricular system development. Predicted to be located in nucleoplasm. Predicted to be part of CAK-ERCC2 complex; transcription factor TFIIH core complex; and transcription factor TFIIK complex. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and hemolymphoid system gland. Orthologous to human MNAT1 (MNAT1 component of CDK activating kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mnat1 |
| Official Name | menage a trois 1 [Source:MGI Symbol;Acc:MGI:106207] |
| Ensembl ID | ENSMUSG00000021103 |
| Bio databases IDs | |
| Aliases | menage a trois 1 |
| Synonyms | CAK ASSEMBLY FACTOR, CAP35, E130115E11RIK, MAT1, menage a trois 1, MNAT1 component of CDK activating kinase, P36, RNF66, TFB3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mnat1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc ion binding
- Ring finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- CDK-activating kinase assembly factor MAT1
- coiled-coil domain
- protein binding
- hydrophobic domain
- zinc-RING finger domain
Pathways
Biological processes and signaling networks where the Mnat1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- epithelial cancer
- prostatic carcinoma
- prostate cancer
- progressive vision loss
- cleft palate
- cleft lip
- rheumatoid arthritis
role in cell
- apoptosis
- proliferation
- outgrowth
- tanespimycin sensitivity
- replication in
- G1 phase
- G1/S phase transition
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- chromosome
- nucleoplasm
- germinal vesicles
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mnat1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of smooth muscle cell proliferation
- ventricular system development
- DNA repair
- negative regulation of apoptotic process
- response to calcium ion
- G1/S transition of mitotic cell cycle
- nucleotide-excision repair
- regulation of G1/S transition of mitotic cell cycle
- transcription initiation from RNA polymerase II promoter
- adult heart development
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- core TFIIH complex
- cyclin-dependent protein kinase holoenzyme complex
- TFIIK complex
- holo TFIIH complex
- CAK-ERCC2 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding