Plxnc1 Gene Summary [Mouse]
Predicted to enable semaphorin receptor activity. Involved in regulation of synapse pruning. Is active in cerebellar climbing fiber to Purkinje cell synapse. Is expressed in several structures, including genitourinary system; heart; nervous system; respiratory system; and sensory organ. Orthologous to human PLXNC1 (plexin C1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plxnc1 |
| Official Name | plexin C1 [Source:MGI Symbol;Acc:MGI:1890127] |
| Ensembl ID | ENSMUSG00000074785 |
| Bio databases IDs | |
| Aliases | plexin C1 |
| Synonyms | 2510048K12Rik, AW742158, CD232, PLEXIN C1, VESPR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plxnc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Plexin repeat
- IPT
- Plexin cytoplasmic RasGAP domain
- protein binding
- receptor binding
- Ras GTPase Activating Domain
- semaphorin domain
- Plexin cytoplasmic RhoGTPase-binding domain
- IPT/TIG domain
- plexin/semaphorin/integrin domain
- Sema domain
- transmembrane receptor
- The Sema domain, a protein interacting module, of semaphorins and plexins
Pathways
Biological processes and signaling networks where the Plxnc1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- prostate cancer
- hypothyroidism
- osteoarthritis
- Alzheimer disease
- asthma
- multiple sclerosis
- atopic dermatitis
- autoimmune disease
- conotruncal heart malformations
role in cell
- migration
- adhesion
- abnormal morphology
- cell spreading
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell surface
- cellular membrane
- growth cone
- synapse
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plxnc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- positive regulation of axonogenesis
- negative regulation of cell adhesion
- regulation of GTPase activity
- cell adhesion
- regulation of cell migration
- semaphorin-plexin signaling pathway
Cellular Component
Where in the cell the gene product is active
- semaphorin receptor complex
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- semaphorin receptor activity
- receptor binding