Dgkb Gene Summary [Mouse]
Enables ATP-dependent diacylglycerol kinase activity. Involved in modulation of chemical synaptic transmission and regulation of postsynapse organization. Acts upstream of or within response to bacterium. Located in plasma membrane. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in anterior abdominal wall musculature; nervous system; retina; and urinary system. Orthologous to human DGKB (diacylglycerol kinase beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dgkb |
| Official Name | diacylglycerol kinase, beta [Source:MGI Symbol;Acc:MGI:2442474] |
| Ensembl ID | ENSMUSG00000036095 |
| Bio databases IDs | |
| Aliases | diacylglycerol kinase, beta |
| Synonyms | 6430574F24, 90-kDa Dg Kinase, C630029D13Rik, Dagk, DAGK2, DGK, Dgk2, DGK-BETA, Dg kinase, 90-kDa, DGK-β, diacylglycerol kinase beta, diacylglycerol kinase, beta, diacylglycerol kinase β, diacylglycerol kinase, β, mKIAA0718 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dgkb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand, calcium binding motif
- lipid binding
- diacylglycerol kinase
- SAM domain
- EF-hand domain pair
- EFh
- Diacylglycerol kinase catalytic domain (presumed)
- kinase
- Diacylglycerol kinase N-terminus
- EF-hand domain
- EF hand
- Diacylglycerol kinase accessory domain
- protein kinase C conserved region 1 (C1 domain) superfamily
- Diacylglycerol kinase catalytic domain
Pathways
Biological processes and signaling networks where the Dgkb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- acute lymphoblastic leukemia
- acute myeloid leukemia
- atrial fibrillation
- major depression
- Huntington disease
- Kawasaki disease
- non-insulin-dependent diabetes mellitus
- chronic obstructive pulmonary disease
- insomnia
regulates
- D-glucose
- diacylglycerol
- GCG
- lipid
- phosphatidic acid
- NADPH oxidase
- 1-stearoyl-2-arachidonyl-sn-glycerol
- Vsvg
- 1-stearoyl-2-linoleoyl-sn-glycerol
- glycerolipid
role in cell
- formation
- accumulation in
- morphology
- activation
- respiratory burst in
- survival
- reassembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- cellular membrane
- Plasma Membrane
- cytosol
- nucleoplasm
- nuclear speckles
- synapse
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dgkb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycerolipid metabolic process
- protein kinase C-activating G-protein coupled receptor signaling pathway
- platelet activation
- intracellular signal transduction
- lipid phosphorylation
- phosphatidic acid biosynthetic process
- diacylglycerol metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- postsynaptic membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- calcium ion binding
- lipid binding
- diacylglycerol kinase activity