DGKB Gene Summary [Human]
Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017]
Details
| Type | Protein Coding |
| Official Symbol | DGKB |
| Official Name | diacylglycerol kinase beta [Source:HGNC Symbol;Acc:HGNC:2850] |
| Ensembl ID | ENSG00000136267 |
| Bio databases IDs | |
| Aliases | diacylglycerol kinase beta |
| Synonyms | 6430574F24, 90-kDa Dg Kinase, C630029D13Rik, Dagk, DAGK2, DGK, Dgk2, DGK-BETA, Dg kinase, 90-kDa, DGK-β, diacylglycerol kinase beta, diacylglycerol kinase, beta, diacylglycerol kinase β, diacylglycerol kinase, β, mKIAA0718 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DGKB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand, calcium binding motif
- lipid binding
- diacylglycerol kinase
- SAM domain
- EF-hand domain pair
- EFh
- Diacylglycerol kinase catalytic domain (presumed)
- kinase
- Diacylglycerol kinase N-terminus
- EF-hand domain
- EF hand
- Diacylglycerol kinase accessory domain
- protein kinase C conserved region 1 (C1 domain) superfamily
- Diacylglycerol kinase catalytic domain
Pathways
Biological processes and signaling networks where the DGKB gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- acute lymphoblastic leukemia
- acute myeloid leukemia
- atrial fibrillation
- major depression
- Huntington disease
- Kawasaki disease
- non-insulin-dependent diabetes mellitus
- chronic obstructive pulmonary disease
- insomnia
regulates
- D-glucose
- diacylglycerol
- GCG
- lipid
- phosphatidic acid
- NADPH oxidase
- 1-stearoyl-2-arachidonyl-sn-glycerol
- Vsvg
- 1-stearoyl-2-linoleoyl-sn-glycerol
- glycerolipid
role in cell
- formation
- accumulation in
- morphology
- activation
- respiratory burst in
- survival
- reassembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- cellular membrane
- Plasma Membrane
- cytosol
- nucleoplasm
- nuclear speckles
- synapse
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DGKB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycerolipid metabolic process
- protein kinase C-activating G-protein coupled receptor signaling pathway
- platelet activation
- intracellular signal transduction
- lipid phosphorylation
- phosphatidic acid biosynthetic process
- diacylglycerol metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- postsynaptic membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- calcium ion binding
- lipid binding
- diacylglycerol kinase activity