Acaa1a Gene Summary [Mouse]
Enables acetyl-CoA C-acyltransferase activity. Involved in fatty acid derivative biosynthetic process and fatty acid metabolic process. Located in peroxisome. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human ACAA1 (acetyl-CoA acyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acaa1a |
| Official Name | acetyl-Coenzyme A acyltransferase 1A [Source:MGI Symbol;Acc:MGI:2148491] |
| Ensembl ID | ENSMUSG00000036138 |
| Bio databases IDs | |
| Aliases | acetyl-Coenzyme A acyltransferase 1A |
| Synonyms | 3-oxoacyl-coa Thiolase, Acaa, Acaa1, Acaa1b, acetyl-CoA acyltransferase 1A, acetyl-Coenzyme A acyltransferase 1A, acetyl-Coenzyme A acyltransferase 1B, D9Ertd25e, Peroxisomal 3-Ketoacyl CoA Thiolase, Peroxisomal thiolase, Pktaa, Pt, PTL, RGD1562373, Thiolase A, Thiolase B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Acaa1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thiolase, N-terminal domain
- cond_enzymes
- acetyl-CoA C-acyltransferase
- peroxisome targeting signal 2
- acetyl-CoA acetyltransferases
- acetate CoA-transferase
- Thiolase, C-terminal domain
- enzyme
- acetyl-CoA C-myristoyltransferase
- protein binding
- Beta-ketoacyl synthase, C-terminal domain
- palmitoyl-CoA oxidase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- proximal tubular toxicity
- early onset hypertension
role in cell
- binding in
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- cytosol
- peroxisomes
- peroxisomal fraction