Trpc5 Gene Summary [Mouse]
Enables calcium channel activity and inositol 1,4,5 trisphosphate binding activity. Involved in neuron apoptotic process and phosphatidylserine exposure on apoptotic cell surface. Is active in presynapse. Is expressed in several structures, including alimentary system; endocrine gland; genitourinary system; immune system; and liver and biliary system. Orthologous to human TRPC5 (transient receptor potential cation channel subfamily C member 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trpc5 |
| Official Name | transient receptor potential cation channel, subfamily C, member 5 [Source:MGI Symbol;Acc:MGI:109524] |
| Ensembl ID | ENSMUSG00000041710 |
| Bio databases IDs | |
| Aliases | transient receptor potential cation channel, subfamily C, member 5 |
| Synonyms | CCE2, PPP1R159, transient receptor potential cation channel subfamily C member 5, transient receptor potential cation channel, subfamily C, member 5, TRP-5, TRRP5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trpc5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ankyrin repeats (many copies)
- Ion transport protein
- calcium channel
- actinin binding
- Ankyrin repeats (3 copies)
- clathrin binding
- store-operated calcium channel
- protein binding
- proline rich domain
- ion channel
- ATPase binding
- binding protein
- actin binding
- Transient receptor ion channel II
- transient-receptor-potential calcium channel protein
- Transient Receptor Potential channel, Vanilloid subfamily (TRPV)
Pathways
Biological processes and signaling networks where the Trpc5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- depressive disorder
- hyperalgesia
- obesity
- anhedonia
- hypoprolactinemia
- non-melanoma skin cancer
- seizures
- insulin-induced hypoglycemia
role in cell
- proliferation
- apoptosis
- activation in
- differentiation
- phosphorylation in
- cell death
- outgrowth
- collapse
- induction in
- density
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- Cytoplasm
- presynaptic regions
- cell surface
- cellular membrane
- Golgi Apparatus
- cytosol
- microsome
- growth cone
- neurites
- nerve ending
- synaptosomes
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trpc5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron differentiation
- positive regulation of cell proliferation
- cytosolic calcium ion homeostasis
- nervous system development
- positive regulation of neuron differentiation
- positive regulation of axon extension
- elevation of cytosolic calcium ion concentration
- negative regulation of dendrite morphogenesis
- phosphatidylserine exposure on apoptotic cell surface
- calcium ion transport
- calcium ion transmembrane transport
- positive regulation of peptidyl-threonine phosphorylation
- neuron apoptotic process
Cellular Component
Where in the cell the gene product is active
- growth cone
- dendrite
- calcium channel complex
- neuronal cell body
- cation channel complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- store-operated calcium channel activity
- protein binding
- actin binding
- actinin binding
- calcium channel activity
- clathrin binding
- inositol 1,4,5 trisphosphate binding
- ATPase binding