Fstl4 Gene Summary [Mouse]
Enables brain-derived neurotrophic factor binding activity. Acts upstream of or within negative regulation of brain-derived neurotrophic factor receptor signaling pathway; negative regulation of collateral sprouting; and negative regulation of dendritic spine development. Located in secretory granule. Is expressed in medulla oblongata basal plate mantle layer; neural retina; olfactory cortex mantle layer; pons mantle layer; and telencephalon mantle layer. Orthologous to human FSTL4 (follistatin like 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fstl4 |
| Official Name | follistatin-like 4 [Source:MGI Symbol;Acc:MGI:2443199] |
| Ensembl ID | ENSMUSG00000036264 |
| Bio databases IDs | |
| Aliases | follistatin-like 4 |
| Synonyms | B230374F23Rik, follistatin-like 4, mKIAA1061, SPIG1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fstl4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin C1-set domain
- Immunoglobulin V-Type
- factor I membrane attack complex
- EF-hand domain pair
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- EFh
- KAZAL_FS
- growth factor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fstl4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of brain-derived neurotrophic factor receptor signaling pathway
- negative regulation of collateral sprouting
- multicellular organismal development
- negative regulation of dendritic spine development
- cell differentiation
- regulation of BMP signaling pathway
Cellular Component
Where in the cell the gene product is active
- secretory granule
- extracellular region
Molecular Function
What the gene product does at the molecular level
- calcium ion binding
- brain-derived neurotrophic factor binding