Misp Gene Summary [Mouse]
Predicted to enable actin filament binding activity. Predicted to be involved in several processes, including establishment of centrosome localization; microtubule cytoskeleton organization involved in mitosis; and regulation of protein localization to cell cortex. Predicted to be located in cytoskeleton; intracellular membrane-bounded organelle; and plasma membrane. Predicted to colocalize with cortical actin cytoskeleton; focal adhesion; and mitotic spindle astral microtubule end. Is expressed in gut. Orthologous to human MISP (mitotic spindle positioning). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Misp |
| Official Name | mitotic spindle positioning [Source:MGI Symbol;Acc:MGI:1926156] |
| Ensembl ID | ENSMUSG00000035852 |
| Bio databases IDs | |
| Aliases | mitotic spindle positioning |
| Synonyms | 9130017N09Rik, C19orf21, MISP1, mitotic spindle positioning |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Misp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- A-kinase anchor protein 2 C-terminus
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cortical actin cytoskeleton
- focal adhesions
- centrosome
- actin filaments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Misp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- establishment of mitotic spindle orientation
- organelle localization
- establishment of centrosome localization
- cell migration
- spindle assembly involved in mitosis
Cellular Component
Where in the cell the gene product is active
- spindle pole centrosome
- focal adhesion
- intracellular membrane-bounded organelle
- actin filament
- plasma membrane
- cortical actin cytoskeleton
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding