Etv3 Gene Summary [Mouse]
Enables DEAD/H-box RNA helicase binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in cellular response to granulocyte macrophage colony-stimulating factor stimulus; negative regulation of cell population proliferation; and negative regulation of transcription by RNA polymerase II. Located in chromatin. Part of RNA polymerase II transcription repressor complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; retina; and thymus primordium. Orthologous to human ETV3 (ETS variant transcription factor 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Etv3 |
| Official Name | ets variant 3 [Source:MGI Symbol;Acc:MGI:1350926] |
| Ensembl ID | ENSMUSG00000003382 |
| Bio databases IDs | |
| Aliases | ets variant 3 |
| Synonyms | ets variant 3, ETS variant transcription factor 3, LOC100045950, METS, PE-1, Spap1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Etv3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- transcription repression domain
- nucleic acid binding
- double-stranded DNA binding
- DEAD/H-box RNA helicase binding
- Ets-domain
- protein binding
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- prostate cancer
- productive infection by HIV-1
role in cell
- expression in
- proliferation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Etv3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- cellular response to granulocyte macrophage colony-stimulating factor stimulus
- negative regulation of cell proliferation
- cell differentiation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- intracellular membrane-bounded organelle
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DEAD/H-box RNA helicase binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity