Wtip Gene Summary [Mouse]
Enables transcription corepressor activity. Predicted to be involved in several processes, including negative regulation of hippo signaling; regulation of gene expression; and response to hypoxia. Predicted to act upstream of or within miRNA-mediated post-transcriptional gene silencing. Predicted to be located in cytosol; focal adhesion; and plasma membrane. Predicted to be part of transcription regulator complex. Predicted to be active in P-body; adherens junction; and nucleus. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; nervous system; and sensory organ. Orthologous to human WTIP (WT1 interacting protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wtip |
| Official Name | WT1-interacting protein [Source:MGI Symbol;Acc:MGI:2141920] |
| Ensembl ID | ENSMUSG00000036459 |
| Bio databases IDs | |
| Aliases | WT1-interacting protein |
| Synonyms | AABR07002945.1, RGD1306411, WT1 interacting protein |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wtip often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PreLIM domain
- transcription regulator
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- transcription co-repressor
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytoplasmic mRNA processing body
- cell periphery
- cell-cell contacts
- cytosol
- plasma membrane projections
- anchoring junction
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wtip gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of hippo signaling cascade
- negative regulation of translation involved in gene silencing by miRNA
- response to hypoxia
- cytoskeleton organization
- negative regulation of transcription, DNA-dependent
- regulation of cell morphogenesis
- gene silencing by miRNA
- cell projection organization
- regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- adherens junction
- cytoplasmic mRNA processing body
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- transcription corepressor activity