WTIP Gene Summary [Human]
Predicted to enable transcription corepressor activity. Involved in several processes, including negative regulation of hippo signaling; positive regulation of gene silencing by miRNA; and response to hypoxia. Acts upstream of or within gene silencing by miRNA. Located in P-body. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | WTIP |
| Official Name | WT1 interacting protein [Source:HGNC Symbol;Acc:HGNC:20964] |
| Ensembl ID | ENSG00000142279 |
| Bio databases IDs | |
| Aliases | WT1 interacting protein, WT1-interacting protein |
| Synonyms | AABR07002945.1, RGD1306411, WT1 interacting protein |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human WTIP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PreLIM domain
- transcription regulator
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- transcription co-repressor
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytoplasmic mRNA processing body
- cell periphery
- cell-cell contacts
- cytosol
- plasma membrane projections
- anchoring junction
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human WTIP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of hippo signaling cascade
- negative regulation of translation involved in gene silencing by miRNA
- response to hypoxia
- cytoskeleton organization
- negative regulation of transcription, DNA-dependent
- regulation of cell morphogenesis
- gene silencing by miRNA
- cell projection organization
- regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- adherens junction
- cytoplasmic mRNA processing body
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- transcription corepressor activity