Mrtfb Gene Summary [Mouse]
Enables DNA-binding transcription factor activity; actin binding activity; and transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including circulatory system development; liver development; and nervous system development. Located in cytoplasm. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; intestine wall; and lung. Orthologous to human MRTFB (myocardin related transcription factor B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mrtfb |
| Official Name | myocardin related transcription factor B [Source:MGI Symbol;Acc:MGI:3050795] |
| Ensembl ID | ENSMUSG00000009569 |
| Bio databases IDs | |
| Aliases | myocardin related transcription factor B |
| Synonyms | GT4-1, KIAA1243, mKIAA1243, MKL2, myocardin related transcription factor B, NPD001, RGD1560833, SOLOIST |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mrtfb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- RPEL repeat
- SAP motif
- SAP domain
- actin binding
- protein binding
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bleeding
- metastasis
- perimembranous ventricular septal defect
- tumorigenesis
- hypoplasia
- thrombocytopenia
- ischemic stroke
- double outlet right ventricle
- edema
- sarcoidosis
role in cell
- expression in
- binding in
- organization
- transactivation in
- accumulation
- activation
- recruitment in
- downregulation in
- differentiation
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- Cytoplasm
- presynaptic regions
- postsynaptic region
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mrtfb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle organ development
- smooth muscle cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of striated muscle tissue development
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- cadherin binding