Decr2 Gene Summary [Mouse]
Predicted to enable 2,4-dienoyl-CoA reductase (NADPH) activity and trans-2-enoyl-CoA reductase (NADPH) activity. Predicted to be involved in unsaturated fatty acid biosynthetic process. Predicted to be located in peroxisomal membrane. Predicted to be active in peroxisome. Orthologous to human DECR2 (2,4-dienoyl-CoA reductase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Decr2 |
| Official Name | 2-4-dienoyl-Coenzyme A reductase 2, peroxisomal [Source:MGI Symbol;Acc:MGI:1347059] |
| Ensembl ID | ENSMUSG00000036775 |
| Bio databases IDs | |
| Aliases | 2-4-dienoyl-Coenzyme A reductase 2, peroxisomal |
| Synonyms | 2,4-dienoyl-CoA reductase 2, 2-4-dienoyl-Coenzyme A reductase 2, peroxisomal, D2, d4-dienoylcoa reductase, Dcrakl, PDCR, putativeperoxisomal24-dienoyl-CoAreductase, SDR17C1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Decr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- polyketide synthase keto reductase domain
- Rossmann-fold NAD(P)(+)-binding proteins
- 2,4-dienoyl-CoA reductase (NADPH2)
- KR domain
- NADP oxidoreductase coenzyme F420-dependent
- pteridine reductase
- enzyme
- protein binding
- Enoyl-(Acyl carrier protein) reductase
- short chain dehydrogenase
- trans-2-enoyl-CoA reductase (NADPH2)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Hodgkin lymphoma
- Hodgkin disease
regulates
- delta3-enoyl-coenzyme A
- delta2-trans,delta4-trans-decadienoyl coenzyme A
- delta2-enoyl coenzyme A
- 2,4,7,10,13,16,19-docosaheptaenoyl-coenzyme A
- polyunsaturated fatty acids
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- peroxisome membrane
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Decr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- unsaturated fatty acid biosynthetic process
- fatty acid beta-oxidation using acyl-CoA oxidase
- fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- peroxisome
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- trans-2-enoyl-CoA reductase (NADPH) activity
- 2,4-dienoyl-CoA reductase (NADPH) activity