Dpp10 Gene Summary [Mouse]
Enables potassium channel regulator activity. Involved in protein localization to plasma membrane and regulation of potassium ion transmembrane transport. Located in plasma membrane. Part of voltage-gated potassium channel complex. Is expressed in cerebral cortex intermediate zone; cerebral cortex marginal layer; cerebral cortex subventricular zone; cortical subplate; and dentate gyrus subgranular zone. Human ortholog(s) of this gene implicated in asthma. Orthologous to human DPP10 (dipeptidyl peptidase like 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dpp10 |
| Official Name | dipeptidylpeptidase 10 [Source:MGI Symbol;Acc:MGI:2442409] |
| Ensembl ID | ENSMUSG00000036815 |
| Bio databases IDs | |
| Aliases | dipeptidylpeptidase 10 |
| Synonyms | 6430601K09RIK, dipeptidylpeptidase 10, dipeptidyl peptidase like 10, DPL2, DPP X, DPPY, DPRP-3, LOC107985938 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dpp10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Prolyl oligopeptidase family
- Dipeptidyl peptidase IV (DPP IV) N-terminal region
- potassium channel regulator
- ion channel binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bipolar disorder
- schizophrenia
- proliferative diabetic retinopathy
- idiopathic scoliosis
- major depression
- acute myeloid leukemia
- suicide attempt
- COVID-19
- ulcerative colitis
- thoracic aortic aneurysms and dissections
role in cell
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- rough endoplasmatic reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dpp10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- voltage-gated potassium channel complex
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- serine-type peptidase activity
- dipeptidyl-peptidase activity
- potassium channel regulator activity
- ion channel binding