Kcnd2 Gene Summary [Mouse]
Enables A-type (transient outward) potassium channel activity and voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in several processes, including locomotor rhythm; neuronal action potential; and potassium ion transmembrane transport. Located in dendritic spine; neuronal cell body; and plasma membrane. Part of voltage-gated potassium channel complex. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic specialization membrane. Is expressed in several structures, including heart; hindlimb digit; metanephros; nervous system; and sensory organ. Orthologous to human KCND2 (potassium voltage-gated channel subfamily D member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnd2 |
| Official Name | potassium voltage-gated channel, Shal-related family, member 2 [Source:MGI Symbol;Acc:MGI:102663] |
| Ensembl ID | ENSMUSG00000060882 |
| Bio databases IDs | |
| Aliases | potassium voltage-gated channel, Shal-related family, member 2 |
| Synonyms | Gm52855, KV4.2, potassium voltage-gated channel, Shal-related family, member 2, potassium voltage-gated channel subfamily D member 2, RK5, Shal1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcnd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- potassium channel
- Ion transport protein
- BTB_POZ
- Domain of unknown function (DUF3399)
- Vsal motif
- protein binding
- ion channel
- voltage-gated potassium channel
- binding protein
- Broad-Complex, Tramtrack and Bric a brac
- BTB/POZ domain
- A-type (transient outward) potassium channel
- Shal-type voltage-gated potassium channels, N-terminal
- voltage-gated ion channel
- Polycystin cation channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- relapsing-remitting multiple sclerosis
- hereditary disorder
- multiple sclerosis
- insomnia
- organismal death
- nonarteritic ischemic optic neuropathy
- primary progressive multiple sclerosis
- atopic dermatitis
- early myoclonic encephalopathy
- nerve injury
role in cell
- apoptosis
- cell death
- proliferation
- repolarization
- hypertrophy
- action potential
- abnormal morphology
- action potential by
- response by
- synaptic transmission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- basal dendrites
- glutaminergic synapse
- cell surface
- cell periphery
- perinuclear region
- cellular membrane
- Nucleus
- Golgi Apparatus
- Endoplasmic Reticulum
- reticular perinuclear compartment
- postsynaptic membrane
- caveolae
- synaptic membrane
- dendritic spines
- synapse
- sarcolemma
- transverse tubules
- membrane rafts
- perikaryon
- dendrites
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcnd2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of postsynaptic membrane potential
- potassium ion transmembrane transport
- regulation of heart contraction
- protein homooligomerization
- synaptic transmission
- membrane repolarization
- locomotor rhythm
- muscle contraction
- sensory perception of pain
- regulation of action potential
- cellular response to hypoxia
- regulation of action potential in neuron
Cellular Component
Where in the cell the gene product is active
- anchoring junction
- postsynaptic membrane
- voltage-gated potassium channel complex
- dendritic spine
- neuronal cell body membrane
- neuronal cell body
- perikaryon
- Kv4.2-KChIP2 channel complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- voltage-gated potassium channel activity
- protein binding
- metal ion binding
- A-type (transient outward) potassium channel activity