Man1c1 Gene Summary [Mouse]
Predicted to enable calcium ion binding activity and mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in ERAD pathway. Predicted to act upstream of or within mannose metabolic process and proteoglycan biosynthetic process. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi membrane and endoplasmic reticulum. Is expressed in several structures, including cerebellum; genitourinary system; gut; hemolymphoid system gland; and liver. Orthologous to human MAN1C1 (mannosidase alpha class 1C member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Man1c1 |
| Official Name | mannosidase, alpha, class 1C, member 1 [Source:MGI Symbol;Acc:MGI:2446214] |
| Ensembl ID | ENSMUSG00000037306 |
| Bio databases IDs | |
| Aliases | mannosidase, alpha, class 1C, member 1 |
| Synonyms | AI593348, HMIC, LOC230815, MAN1A3, MAN1C, mannosidase alpha class 1C member 1, mannosidase, alpha, class 1C, member 1, mannosidase α class 1C member 1, mannosidase, α, class 1C, member 1, pp6318, α 1,2 mannosidase ic |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Man1c1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyl hydrolase family 47
- mannosyl-oligosaccharide 1,2-alpha-mannosidase
- calcium ion binding
- Cyclases involved in the biosynthesis of lantibiotics, and similar proteins
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Man1c1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- protein N-linked glycosylation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- Golgi membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- mannosyl-oligosaccharide 1,2-alpha-mannosidase activity