Ikzf3 Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in lymphocyte differentiation; positive regulation of transcription by RNA polymerase II; and regulation of B cell activation. Acts upstream of or within response to bacterium. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and liver and biliary system. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in immunodeficiency 84. Orthologous to human IKZF3 (IKAROS family zinc finger 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ikzf3 |
| Official Name | IKAROS family zinc finger 3 [Source:MGI Symbol;Acc:MGI:1342542] |
| Ensembl ID | ENSMUSG00000018168 |
| Bio databases IDs | |
| Aliases | IKAROS family zinc finger 3 |
| Synonyms | 5830411O07Rik, AIO, AIOLOS, IKAROS family zinc finger 3, IMD84, Zfp1a3, Zfpn1a3, ZNFN1A3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ikzf3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- C2H2-type zinc-finger domain
- histone deacetylase binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- identical protein binding
- double-stranded DNA binding
- Zinc-finger double domain
- protein homodimerization
- zinc finger domain
- transcription factor activity
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardiovascular disorder
- proteinuria
- chronic lymphocytic leukemia
- cancer
- blastic plasmacytoid dendritic cell neoplasm
- rheumatoid arthritis
- COVID-19
- diabetic nephropathy
- B cell cancer
- mature B-cell neoplasia
role in cell
- quantity
- proliferation
- cell viability
- expression in
- apoptosis
- activation in
- differentiation
- development
- number
- homing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear speckles
- toroidal chromatin structures
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ikzf3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of B cell proliferation
- T cell differentiation
- regulation of lymphocyte differentiation
- response to bacterium
- B cell differentiation
- mesoderm development
- regulation of B cell differentiation
- regulation of apoptotic process
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- protein homodimerization activity
- histone deacetylase binding
- protein heterodimerization activity
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding