Kdm6a Gene Summary [Mouse]
Enables DNA binding activity; histone H3K27me2/H3K27me3 demethylase activity; and identical protein binding activity. Involved in chromatin remodeling. Acts upstream of or within several processes, including chordate embryonic development; embryonic morphogenesis; and respiratory system process. Located in nucleus. Part of histone methyltransferase complex. Is expressed in several structures, including alimentary system; early conceptus; gonad; liver; and spleen. Used to study chronic myelomonocytic leukemia. Human ortholog(s) of this gene implicated in several diseases, including Kabuki syndrome; bladder urothelial carcinoma; gastrointestinal system cancer (multiple); lung carcinoma (multiple); and triple-receptor negative breast cancer. Orthologous to human KDM6A (lysine demethylase 6A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kdm6a |
| Official Name | lysine (K)-specific demethylase 6A [Source:MGI Symbol;Acc:MGI:1095419] |
| Ensembl ID | ENSMUSG00000037369 |
| Bio databases IDs | |
| Aliases | lysine (K)-specific demethylase 6A |
| Synonyms | bA386N14.2, KABUK2, lysine demethylase 6A, lysine (K)-specific demethylase 6A, UTX |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kdm6a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleic acid binding
- 2-oxoglutarate:oxygen oxidoreductase
- chromatin binding
- enzyme
- protein binding
- sequence-specific DNA binding
- identical protein binding
- RmlC-like cupin superfamily
- DNA binding
- double-stranded DNA binding
- Tetratricopeptide repeats
- type IV pilus biogenesis/stability protein PilW
- tetratricopeptide repeat
- histone demethylase activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- advanced cancer
- neoplasia
- epithelial cancer
- tumorigenesis
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- lung squamous cell carcinoma
- squamous cell lung cancer
- medulloblastoma
role in cell
- apoptosis
- activation in
- proliferation
- expression in
- migration
- accumulation in
- quantity
- Gap 0-Gap 1 phase
- infiltration by
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kdm6a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- chromatin remodeling
- regulation of gene expression
Cellular Component
Where in the cell the gene product is active
- nucleus
- histone methyltransferase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- histone demethylase activity
- histone demethylase activity (H3-K27 specific)