Nlrc5 Gene Summary [Mouse]
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in innate immune response; negative regulation of NF-kappaB transcription factor activity; and negative regulation of type I interferon-mediated signaling pathway. Acts upstream of or within response to bacterium. Located in cytosol and nucleus. Is expressed in liver. Orthologous to human NLRC5 (NLR family CARD domain containing 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Nlrc5 |
| Official Name | NLR family, CARD domain containing 5 [Source:MGI Symbol;Acc:MGI:3612191] |
| Ensembl ID | ENSMUSG00000074151 |
| Bio databases IDs | |
| Aliases | NLR family, CARD domain containing 5 |
| Synonyms | AI451557, CLR16.1, Cpne2, LOC100912184, LOC102553150, LOC102553241, LOC108348892, NLR family CARD domain containing 5, NLR family, CARD domain containing 5, NOD27, NOD4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nlrc5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NLRC4 helical domain HD2
- transcription regulator
- protein phosphatase 1 regulatory subunit 42
- nucleic acid binding
- walker type A motif
- Leucine rich repeat
- protein binding
- Leucine Rich repeats (2 copies)
- NACHT domain
- sequence-specific DNA binding
- effector domain
- Atypical caspase recruitment domain
- nucleotide-binding domain
- leucine-rich repeat
- double-stranded DNA binding
- Leucine rich repeat, ribonuclease inhibitor type
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Pathways
Biological processes and signaling networks where the Nlrc5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- multiple sclerosis
- systemic lupus erythematosus
- schizophrenia
- bipolar disorder
- survival
- metabolic syndrome X
- depressive disorder
- dextran sodium sulfate-induced colitis
- leukopenia
role in cell
- expression in
- production in
- phosphorylation in
- activation in
- quantity
- number
- binding in
- replication in
- activation
- M1 polarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- centrosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nlrc5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of kinase activity
- response to bacterium
- negative regulation of NF-kappaB transcription factor activity
- innate immune response
- positive regulation of type I interferon-mediated signaling pathway
- negative regulation of type I interferon-mediated signaling pathway
- defense response to virus
- positive regulation of MHC class I biosynthetic process
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of interferon-gamma-mediated signaling pathway
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding