Kdm6a Gene Summary [Rat]
Predicted to enable DNA binding activity; histone H3K27me2/H3K27me3 demethylase activity; and identical protein binding activity. Involved in several processes, including cellular response to peptide hormone stimulus; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway; and positive regulation of cell size. Predicted to be located in nucleus. Predicted to be part of MLL3/4 complex. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in several diseases, including Kabuki syndrome; bladder urothelial carcinoma; gastrointestinal system cancer (multiple); lung carcinoma (multiple); and triple-receptor negative breast cancer. Orthologous to human KDM6A (lysine demethylase 6A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Kdm6a |
| Official Name | lysine demethylase 6A [Source:RGD Symbol;Acc:9275041] |
| Ensembl ID | ENSRNOG00000052721 |
| Bio databases IDs | |
| Aliases | lysine demethylase 6A |
| Synonyms | bA386N14.2, KABUK2, lysine demethylase 6A, lysine (K)-specific demethylase 6A, UTX |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kdm6a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleic acid binding
- 2-oxoglutarate:oxygen oxidoreductase
- chromatin binding
- enzyme
- protein binding
- sequence-specific DNA binding
- identical protein binding
- RmlC-like cupin superfamily
- DNA binding
- double-stranded DNA binding
- Tetratricopeptide repeats
- type IV pilus biogenesis/stability protein PilW
- tetratricopeptide repeat
- histone demethylase activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- advanced cancer
- neoplasia
- epithelial cancer
- tumorigenesis
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- lung squamous cell carcinoma
- squamous cell lung cancer
- medulloblastoma
role in cell
- apoptosis
- activation in
- proliferation
- expression in
- migration
- accumulation in
- quantity
- Gap 0-Gap 1 phase
- infiltration by
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kdm6a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- chromatin remodeling
- regulation of gene expression
Cellular Component
Where in the cell the gene product is active
- nucleus
- histone methyltransferase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- histone demethylase activity
- histone demethylase activity (H3-K27 specific)