Zbtb42 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleoplasm. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to human ZBTB42 (zinc finger and BTB domain containing 42). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zbtb42 |
| Official Name | zinc finger and BTB domain containing 42 [Source:MGI Symbol;Acc:MGI:3644133] |
| Ensembl ID | ENSMUSG00000037638 |
| Bio databases IDs | |
| Aliases | zinc finger and BTB domain containing 42 |
| Synonyms | EG382639, Gm5188, LCCS6, simiRP58, zinc finger and BTB domain containing 42, ZINC FINGER- AND BTB DOMAIN-CONTAINING PROTEIN 42: ZBTB42, ZNF925 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zbtb42 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- Zinc-finger double domain
- BTB/POZ domain
- protein binding
- C2H2-type zinc finger
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- prostatic carcinoma
- prostate cancer
- global developmental delay with intellectual disability
- lethal congenital contracture syndrome type 6
regulates
- DNA endogenous promoter
- RNA polymerase II
- DNA promoter
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zbtb42 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle organ development
- negative regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- metal ion binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity