Blk

Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; peptidyl-tyrosine phosphorylation; and positive regulation of insulin secretion. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Is expressed in several structures, including 2-cell stage embryo; central nervous system; ileum; male reproductive gland or organ; and peripheral nervous system. Human ortholog(s) of this gene implicated in maturity-onset diabetes of the young type 11 and systemic lupus erythematosus. Orthologous to human BLK (BLK proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Blk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Blk gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Blk gene, providing context for its role in the cell.