Ubash3a Gene Summary [Mouse]
Acts upstream of or within negative regulation of T cell receptor signaling pathway and regulation of cytokine production. Predicted to be located in cytosol and nuclear speck. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skin. Orthologous to human UBASH3A (ubiquitin associated and SH3 domain containing A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ubash3a |
| Official Name | ubiquitin associated and SH3 domain containing, A [Source:MGI Symbol;Acc:MGI:1926074] |
| Ensembl ID | ENSMUSG00000042345 |
| Bio databases IDs | |
| Aliases | ubiquitin associated and SH3 domain containing, A |
| Synonyms | 5830413C03Rik, C330001M22, CLIP4, Gm4102, LOC100044380, LOC100134052, STS-2, TULA, TULA-1, ubiquitin associated and SH3 domain containing A, ubiquitin associated and SH3 domain containing, A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ubash3a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- Histidine phosphatase superfamily (branch 1)
- Phosphoglycerate mutase family
- proline glycine methionine motif
- enzyme
- protein binding
- alpha-ribazole phosphatase
- Histidine phosphatase domain
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- rheumatoid arthritis
- insulin-dependent diabetes mellitus
- autoimmune disease
- diabetic nephropathy
- Graves disease
- vitiligo
- hypothyroidism
- experimental autoimmune encephalomyelitis
- celiac disease
role in cell
- apoptosis
- number
- binding in
- proliferation
- transformation
- tyrosine phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ubash3a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of T cell receptor signaling pathway
- regulation of cytokine production
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- nuclear speck
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding