Mbl1 Gene Summary [Mouse]
Predicted to enable several functions, including D-mannose binding activity; calcium-dependent carbohydrate binding activity; and phosphatidylinositol-4-phosphate binding activity. Acts upstream of or within defense response to other organism and positive regulation of phagocytosis. Located in extracellular space. Orthologous to human MBL1P (mannose binding lectin 1, pseudogene). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mbl1 |
| Official Name | mannose-binding lectin (protein A) 1 [Source:MGI Symbol;Acc:MGI:96923] |
| Ensembl ID | ENSMUSG00000037780 |
| Bio databases IDs | |
| Aliases | mannose-binding lectin (protein A) 1 |
| Synonyms | mannose binding lectin 1, mannose-binding lectin (protein A) 1, MBL, MBL-A, MBP-A, Mlb1, S-MBP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mbl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- protease binding
- protein homodimerization
- Lectin C-type domain
- calcium ion binding
- protein binding
- carbohydrate binding
- polysaccharide binding
- identical protein binding
- mannose binding
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- reperfusion injury
- Staphylococcus aureus pneumonia
- infection by bacteria
- infection by parasite
regulated by
- pirinixic acid
- Hbb-b2
- Hbb-b1
- PPAR
role in cell
- quantity
- number
- phagocytosis by
- clearance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- Golgi Apparatus
- Endoplasmic Reticulum