Mbl1 Gene Summary [Rat]
Enables several functions, including D-mannose binding activity; calcium-dependent carbohydrate binding activity; and phosphatidylinositol-4-phosphate binding activity. Involved in complement activation, lectin pathway and protein homotrimerization. Located in extracellular space. Orthologous to human MBL1P (mannose binding lectin 1, pseudogene). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mbl1 |
| Official Name | mannose-binding lectin (protein A) 1 [Source:RGD Symbol;Acc:3055] |
| Ensembl ID | ENSRNOG00000011706 |
| Bio databases IDs | |
| Aliases | mannose-binding lectin (protein A) 1 |
| Synonyms | mannose binding lectin 1, mannose-binding lectin (protein A) 1, MBL, MBL-A, MBP-A, Mlb1, S-MBP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mbl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- protease binding
- protein homodimerization
- Lectin C-type domain
- calcium ion binding
- protein binding
- carbohydrate binding
- polysaccharide binding
- identical protein binding
- mannose binding
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- reperfusion injury
- Staphylococcus aureus pneumonia
- infection by bacteria
- infection by parasite
regulated by
- pirinixic acid
- Hbb-b2
- Hbb-b1
- PPAR
role in cell
- quantity
- number
- phagocytosis by
- clearance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- Golgi Apparatus
- Endoplasmic Reticulum