Masp2 Gene Summary [Mouse]
Predicted to enable several functions, including calcium-dependent protein binding activity; complement component C4b binding activity; and serine-type endopeptidase activity. Predicted to be involved in complement activation, lectin pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain and liver. Orthologous to human MASP2 (MBL associated serine protease 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Masp2 |
| Official Name | mannan-binding lectin serine peptidase 2 [Source:MGI Symbol;Acc:MGI:1330832] |
| Ensembl ID | ENSMUSG00000028979 |
| Bio databases IDs | |
| Aliases | mannan-binding lectin serine peptidase 2 |
| Synonyms | MAP19, MAP-2, MASP1P1, MBL associated serine protease 2, sMAP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Masp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- Trypsin-like serine protease
- Tryp_SPc
- CUB-EGF module pair
- peptidase
- serine protease domain
- protein binding
- identical protein binding
- EGF-like domain
- EGF_CA
- CCP
- trypsin
- serine endopeptidase
- CUB
- Sushi repeat (SCR repeat)
- Coagulation Factor Xa inhibitory site
- SUSHI repeat
Pathways
Biological processes and signaling networks where the Masp2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- non-insulin-dependent diabetes mellitus
- hepatitis B virus-related hepatocellular carcinoma
- liver cancer
- hepatocellular carcinoma
- MASP2 deficiency
- reperfusion injury
- diabetic nephropathy
- renal cell carcinoma
- renal cell cancer
role in cell
- infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Masp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- complement activation, lectin pathway
- complement activation, classical pathway
- proteolysis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- complement component C4b binding
- calcium ion binding
- serine-type endopeptidase activity
- calcium-dependent protein binding
- peptidase activity