Dennd4c Gene Summary [Mouse]
Enables guanyl-nucleotide exchange factor activity. Involved in cellular response to insulin stimulus and protein localization to plasma membrane. Located in cytosol; insulin-responsive compartment; and plasma membrane. Part of retromer complex. Orthologous to human DENND4C (DENN domain containing 4C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dennd4c |
| Official Name | DENN/MADD domain containing 4C [Source:MGI Symbol;Acc:MGI:1914769] |
| Ensembl ID | ENSMUSG00000038024 |
| Bio databases IDs | |
| Aliases | DENN/MADD domain containing 4C |
| Synonyms | 1700065A05Rik, bA513M16.3, C9orf55, C9orf55B, DENN domain containing 4C, LOC100420355, LOC102555797, RAB10GEF, RGD1308489 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dennd4c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DENN (AEX-3) domain
- guanyl-nucleotide exchange factor
- Stabilization of polarity axis
- dDENN domain
- uDENN domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- cytosol
- GLUT4 vesicles
- secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dennd4c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to insulin stimulus
- regulation of Rab protein signal transduction
- protein transport
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle membrane
- insulin-responsive compartment
- intracellular membrane-bounded organelle
- retromer complex
- cytoplasmic vesicle
- cytosol
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- guanyl-nucleotide exchange factor activity