Lamtor1 Gene Summary [Mouse]
Enables protein-membrane adaptor activity. Involved in several processes, including lysosome localization; positive regulation of intracellular signal transduction; and regulation of receptor recycling. Is active in lysosomal membrane. Is expressed in several structures, including adipose tissue; alimentary system; early conceptus; nervous system; and reproductive system. Orthologous to human LAMTOR1 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lamtor1 |
| Official Name | late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 [Source:MGI Symbol;Acc:MGI:1913758] |
| Ensembl ID | ENSMUSG00000030842 |
| Bio databases IDs | |
| Aliases | late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 |
| Synonyms | 2400001E08Rik, C11orf59, FLJ20625, late endosomal/lysosomal adaptor, MAPK and MTOR activator 1, p18, p27RF-Rho, PDRO, Ragulator1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lamtor1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Late endosomal/lysosomal adaptor and MAPK and MTOR activator
- guanyl-nucleotide exchange factor
- protein binding activity, bridging
- enzyme binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- bleeding
role in cell
- phosphorylation in
- expression in
- number
- proliferation
- formation in
- growth
- formation
- function
- invasion by
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- lysosome
- secretory granule membrane
- specific granule membrane
- lysosome membrane
- endosomal membrane
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lamtor1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lysosome organization
- endosome organization
- protein localization
- positive regulation of MAPK cascade
- regulation of cholesterol import
- cholesterol homeostasis
- lysosome localization
- cellular response to amino acid stimulus
- cellular response to nutrient levels
- regulation of cell growth
- endosomal transport
- protein localization in membrane
- regulation of cholesterol efflux
- positive regulation of TOR signaling cascade
- regulation of receptor recycling
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- extracellular vesicular exosome
- membrane raft
- Ragulator complex
- azurophil granule membrane
- lysosomal membrane
- plasma membrane
- lysosome
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein anchor
- GTPase binding
- guanyl-nucleotide exchange factor activity
- binding, bridging