Skp1 Gene Summary [Mouse]
Predicted to enable several functions, including F-box domain binding activity; beta-catenin binding activity; and cullin family protein binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Acts upstream of or within protein K48-linked ubiquitination and protein monoubiquitination. Located in centrosome and cytosol. Part of Cul7-RING ubiquitin ligase complex and SCF ubiquitin ligase complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; notochord; and sensory organ. Orthologous to human SKP1 (S-phase kinase associated protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Skp1 |
| Official Name | S-phase kinase-associated protein 1 [Source:MGI Symbol;Acc:MGI:103575] |
| Ensembl ID | ENSMUSG00000036309 |
| Bio databases IDs | |
| Aliases | S-phase kinase-associated protein 1 |
| Synonyms | 2610043E24Rik, 2610206H23Rik, EMC19, OCP2, OCP-II, p19A, p19Skp1, SKP1A, S-phase kinase-associated protein 1, S phase kinase associated protein 1a, TCEB1L |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Skp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Skp1 family, dimerization domain
- transcription regulator
- beta-catenin binding
- BTB_POZ
- protein binding activity, bridging
- protein domain specific binding
- protein binding
Pathways
Biological processes and signaling networks where the Skp1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- aortic valve calcification
- androgenic alopecia
- serous ovarian adenocarcinoma
- serous ovarian cancer
- osteogenesis imperfecta type III
- lung cancer
role in cell
- growth
- degradation in
- survival
- depletion
- remodeling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- pericentriolar regions
- centrosome
- cytosol
- centriolar appendages
- nucleoplasm
- gap junctions
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Skp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- proteasomal ubiquitin-dependent protein catabolic process
- protein K48-linked ubiquitination
- protein polyubiquitination
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- protein monoubiquitination
- maintenance of protein location in nucleus
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- PcG protein complex
- cytosol
- SCF ubiquitin ligase complex
- nucleoplasm
- Cul7-RING ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- beta-catenin binding