Pigu Gene Summary [Mouse]
Predicted to contribute to GPI anchor binding activity. Predicted to be involved in GPI anchor biosynthetic process; attachment of GPI anchor to protein; and regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in plasma membrane. Predicted to be part of GPI-anchor transamidase complex. Is expressed in 1st branchial arch; forebrain; and limb. Orthologous to human PIGU (phosphatidylinositol glycan anchor biosynthesis class U). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pigu |
| Official Name | phosphatidylinositol glycan anchor biosynthesis, class U [Source:MGI Symbol;Acc:MGI:3039607] |
| Ensembl ID | ENSMUSG00000038383 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol glycan anchor biosynthesis, class U |
| Synonyms | 5430426F17Rik, CDC91L1, GAB1, GPIBD21, LOC108350506, LRRGT00059, NEDBSS, phosphatidylinositol glycan anchor biosynthesis class U, phosphatidylinositol glycan anchor biosynthesis, class U, sakura |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pigu often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid binding
- binding protein
- GPI-anchor transamidase
- enzyme
- protein binding
- phosphatidylinositol binding
- dolichyl-phosphate-mannose-protein mannosyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- epithelial cancer
- melanoma
- melanoma cancer
- ischemic stroke
- colorectal cancer
- postmenopausal osteoporosis
- colorectal adenoma
- colorectal adenoma formation
- neurodevelopmental disorder with brain anomalies, seizures, and scoliosis
regulated by
- L-glutamic acid
- phycocyanobilin
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- Plasma Membrane
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pigu gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- GPI anchor biosynthetic process
- regulation of JAK-STAT cascade
- attachment of GPI anchor to protein
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- plasma membrane
- GPI-anchor transamidase complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- GPI anchor binding