Ciart Gene Summary [Mouse]
Enables E-box binding activity. Involved in circadian regulation of gene expression; locomotor rhythm; and negative regulation of DNA-templated transcription. Located in nucleus. Orthologous to human CIART (circadian associated repressor of transcription). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ciart |
| Official Name | circadian associated repressor of transcription [Source:MGI Symbol;Acc:MGI:2684975] |
| Ensembl ID | ENSMUSG00000038550 |
| Bio databases IDs | |
| Aliases | circadian associated repressor of transcription |
| Synonyms | C1orf51, CHRONO, circadian associated repressor of transcription, GM129, LOC682372, LOC690012, RGD1566380 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ciart often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- double-stranded DNA binding
- nucleic acid binding
- protein binding
- sequence-specific DNA binding
- Circadian-associated transcriptional repressor
Pathways
Biological processes and signaling networks where the Ciart gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ciart gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- circadian regulation of gene expression
- negative regulation of transcription, DNA-dependent
- locomotor rhythm
Cellular Component
Where in the cell the gene product is active
- nucleus
- PML body
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- E-box binding