Blvra Gene Summary [Mouse]
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; biliverdin reductase [NAD(P)+] activity; and protein serine/threonine kinase activity. Acts upstream of or within several processes, including apoptotic DNA fragmentation; cell surface receptor signaling pathway; and intracellular signaling cassette. Is active in cell surface; cytoplasm; and nucleus. Is expressed in decidua; myometrium; placenta; and spongiotrophoblast. Orthologous to human BLVRA (biliverdin reductase A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Blvra |
| Official Name | biliverdin reductase A [Source:MGI Symbol;Acc:MGI:88170] |
| Ensembl ID | ENSMUSG00000001999 |
| Bio databases IDs | |
| Aliases | biliverdin reductase A |
| Synonyms | 0610006A11Rik, 2500001N03Rik, biliverdin reductase A, BLVR, BVR, BVRA, BVRalpha |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Blvra often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- protein serine/threonine kinase
- nucleotide binding
- nucleic acid binding
- nuclear localization sequence
- Oxidoreductase family, NAD-binding Rossmann fold
- Homoserine dehydrogenase, NAD binding domain
- enzyme
- protein binding
- sequence-specific DNA binding
- biliverdin reductase
- double-stranded DNA binding
- Biliverdin reductase, catalytic
Pathways
Biological processes and signaling networks where the Blvra gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- aortic valve calcification
- hyperbiliverdinemia
- hepatic steatosis
- progressive familial intrahepatic cholestasis type 1
- breast cancer
role in cell
- binding in
- expression in
- phosphorylation in
- apoptosis
- number
- migration
- uptake in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- perinuclear region
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Blvra gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heme catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- zinc ion binding
- protein binding
- biliverdin reductase activity