Fndc4 Gene Summary [Mouse]
Involved in negative regulation of inflammatory response. Located in endoplasmic reticulum; extracellular space; and plasma membrane. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Orthologous to human FNDC4 (fibronectin type III domain containing 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fndc4 |
| Official Name | fibronectin type III domain containing 4 [Source:MGI Symbol;Acc:MGI:1917195] |
| Ensembl ID | ENSMUSG00000038552 |
| Bio databases IDs | |
| Aliases | fibronectin type III domain containing 4 |
| Synonyms | 2810430J06Rik, 6330410H20Rik, AABR07063279.1, fibronectin type III domain containing 4, Fnmp1, FRCP1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fndc4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FN3
- Fibronectin type 3 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- rheumatoid arthritis
- hepatocellular carcinoma
- liver cancer
- diabetic nephropathy
- weight loss
- colitis
regulated by
- chlorcyclizine
- tamoxifen
- zimelidine
- fluoxetine
- amitriptyline
- imipramine
- perhexiline
- chloropromazine
- thioridazine
- ZNFX1
role in cell
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Plasma Membrane
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fndc4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of inflammatory response
- response to transforming growth factor beta stimulus
Cellular Component
Where in the cell the gene product is active
- extracellular space
- endoplasmic reticulum
- plasma membrane