Lima1 Gene Summary [Mouse]
Enables actin filament binding activity. Involved in several processes, including cholesterol homeostasis; intestinal cholesterol absorption; and ruffle organization. Located in actin cytoskeleton; brush border membrane; and ruffle. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and respiratory system. Orthologous to human LIMA1 (LIM domain and actin binding 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lima1 |
| Official Name | LIM domain and actin binding 1 [Source:MGI Symbol;Acc:MGI:1920992] |
| Ensembl ID | ENSMUSG00000023022 |
| Bio databases IDs | |
| Aliases | LIM domain and actin binding 1 |
| Synonyms | EPLIN, LDLCQ8, LIM domain and actin binding 1, SREBP3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lima1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- actin monomer binding
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- protein binding
- Serine Proline motif
- phosphorylation site
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cardiovascular disorder
- hypertension
- colorectal carcinoma
- colorectal carcinomagenesis
- schizophrenia
- colorectal cancer
- breast cancer
- breast carcinoma
- endometrium tumor
role in cell
- expression in
- invasion by
- formation
- formation in
- growth
- quantity
- proliferation
- migration
- invasiveness
- epithelial-mesenchymal transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ruffle
- cytoskeleton
- focal adhesions
- actin cytoskeleton
- Plasma Membrane
- actin filaments
- cytosol
- actin stress fibers
- brush border
- cleavage furrow
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lima1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of actin filament depolymerization
- ruffle organization
- cholesterol metabolic process
- intestinal cholesterol absorption
- cell migration
- cholesterol homeostasis
- actin filament bundle assembly
Cellular Component
Where in the cell the gene product is active
- brush border membrane
- focal adhesion
- cleavage furrow
- stress fiber
- ruffle
- actin cytoskeleton
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- metal ion binding
- cadherin binding
- actin monomer binding