Znfx1 Gene Summary [Mouse]
Enables RNA binding activity. Involved in activation of innate immune response; defense response to virus; and negative regulation of viral genome replication. Is active in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in immunodeficiency 91. Orthologous to human ZNFX1 (zinc finger NFX1-type containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Znfx1 |
| Official Name | zinc finger, NFX1-type containing 1 [Source:MGI Symbol;Acc:MGI:2138982] |
| Ensembl ID | ENSMUSG00000039501 |
| Bio databases IDs | |
| Aliases | zinc finger, NFX1-type containing 1 |
| Synonyms | Ab1-133, AI481105, Astx3, IMD91, KIAA1404, LOC686701, RGD1306344, zinc finger NFX1-type containing 1, zinc finger, NFX1-type containing 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Znfx1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Late cornified envelope-like proline-rich protein 1
- DNA helicase, putative
- Family of unknown function (DUF6539)
- P-loop containing Nucleoside Triphosphate Hydrolases
- AAA domain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- immunodeficiency 91 and hyperinflammation
- early missed abortion
role in cell
- expression in
- activation in
- phosphorylation in
- production in
- proliferation
- generation in
- migration
- replication in
- colony formation
- sphere formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- mitochondrial outer membrane
- stress granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Znfx1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- activation of innate immune response
- innate immune response
- defense response to virus
- negative regulation of viral genome replication
- defense response to bacterium
- chromatin silencing by small RNA
Cellular Component
Where in the cell the gene product is active
- nuclear RNA-directed RNA polymerase complex
- cytoplasmic stress granule
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- RNA binding
- helicase activity