Reep3 Gene Summary [Mouse]
Predicted to enable microtubule binding activity. Predicted to be involved in endoplasmic reticulum tubular network organization and mitotic nuclear membrane reassembly. Predicted to be located in microtubule. Predicted to be active in cytoplasmic microtubule; endoplasmic reticulum membrane; and endoplasmic reticulum tubular network. Is expressed in several structures, including heart valve; limb segment; trigeminal ganglion; and ventricular layer. Orthologous to human REEP3 (receptor accessory protein 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Reep3 |
| Official Name | receptor accessory protein 3 [Source:MGI Symbol;Acc:MGI:88930] |
| Ensembl ID | ENSMUSG00000019873 |
| Bio databases IDs | |
| Aliases | receptor accessory protein 3 |
| Synonyms | C10orf74, D10Ucla1, receptor accessory protein 3, RGD1560401, Yip2b |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Reep3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TB2/DP1, HVA22 family
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- atrial fibrillation
- IgA nephropathy
- metabolic syndrome X
- neoplasia
- idiopathic perifoveal telangiectasia
- metastasis
- organismal death
- venous thromboembolism
- colorectal cancer
role in cell
- proliferation
- binding in
- organization
- transcription in
- reassembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Reep3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- mitotic nuclear envelope reassembly
- nuclear envelope organization
- endoplasmic reticulum tubular network organization
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum tubular network
- cytoplasmic microtubule
Molecular Function
What the gene product does at the molecular level
- protein binding
- microtubule binding