Gabpb2 Gene Summary [Mouse]
Enables identical protein binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human GABPB2 (GA binding protein transcription factor subunit beta 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gabpb2 |
| Official Name | GA repeat binding protein, beta 2 [Source:MGI Symbol;Acc:MGI:95612] |
| Ensembl ID | ENSMUSG00000038766 |
| Bio databases IDs | |
| Aliases | GA repeat binding protein, beta 2 |
| Synonyms | 1810015F01RIK, 5830427M07, 9430006E19Rik, A430024B14Rik, GA binding protein transcription factor subunit beta 2, GA binding protein transcription factor subunit β 2, Gabpb2-1, GA repeat binding protein, beta 2, GA repeat binding protein, β 2, RGD1565234 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gabpb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Ankyrin repeats (many copies)
- double-stranded DNA binding
- nucleic acid binding
- Ankyrin repeats (3 copies)
- protein binding
- sequence-specific DNA binding
- identical protein binding
- Ankyrin repeat
- ankyrin repeats
Pathways
Biological processes and signaling networks where the Gabpb2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atopic dermatitis
- COVID-19
- prostate cancer
- gastric adenocarcinoma
- gastric epithelial cancer
- productive infection by HIV-1
regulates
- RNA polymerase II
- DNA promoter
- DNA endogenous promoter
role in cell
- proliferation
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gabpb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- transcription regulatory region sequence-specific DNA binding