Gorasp2 Gene Summary [Mouse]
Acts upstream of or within response to unfolded protein. Predicted to be located in Golgi medial cisterna; Golgi membrane; and endoplasmic reticulum membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including brain and retina nuclear layer. Orthologous to human GORASP2 (golgi reassembly stacking protein 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gorasp2 |
| Official Name | golgi reassembly stacking protein 2 [Source:MGI Symbol;Acc:MGI:2135962] |
| Ensembl ID | ENSMUSG00000014959 |
| Bio databases IDs | |
| Aliases | golgi reassembly stacking protein 2 |
| Synonyms | 0610011A07Rik, 2410043M02Rik, 5730520M13Rik, 9430094F20Rik, golgi reassembly stacking protein 2, GOLPH2, GOLPH6, GRASP55, GRS2, LOC103690018, p59 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gorasp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GRASP55/65 PDZ-like domain
- canonical PDZ domain
- protein binding
- cpPDZ_Deg_HtrA-like
- PDZ domain
- phosphorylation site
- cpPDZ_RseP_YlbL-like
Pathways
Biological processes and signaling networks where the Gorasp2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- oligozoospermia
- asthenozoospermia
- growth failure
role in cell
- morphology
- quantity
- formation
- maturation
- formation in
- abnormal morphology
- assembly
- organization
- unlinking
- stacking
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi-enriched fraction
- perinuclear region
- cellular membrane
- Golgi Apparatus
- endoplasmic reticulum membrane
- Golgi membrane
- Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gorasp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- organelle assembly
- spermatogenesis
- Golgi organization
- cell differentiation
- organelle organization
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cis-Golgi network
- membrane
- Golgi membrane
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- protein binding