Ccnk Gene Summary [Mouse]
Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity; protein kinase binding activity; and protein serine/threonine kinase activity. Acts upstream of or within in utero embryonic development and negative regulation of stem cell differentiation. Predicted to be located in nucleoplasm. Predicted to be part of cyclin K-CDK12 complex; cyclin K-CDK13 complex; and cyclin/CDK positive transcription elongation factor complex. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; embryo ectoderm; olfactory epithelium; and retina nuclear layer. Orthologous to human CCNK (cyclin K). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccnk |
| Official Name | cyclin K [Source:MGI Symbol;Acc:MGI:1276106] |
| Ensembl ID | ENSMUSG00000021258 |
| Bio databases IDs | |
| Aliases | cyclin K |
| Synonyms | CPR4, CycK, cyclin K, IDDHDF |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ccnk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- cyclin-dependent protein kinase
- protein serine/threonine kinase
- [RNA-polymerase]-subunit kinase
- protein kinase binding
- Cyclin box fold superfamily
- domain present in cyclins, TFIIB and Retinoblastoma
- protein binding
Pathways
Biological processes and signaling networks where the Ccnk gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- intellectual developmental disorder with hypertelorism and distinctive facies
- endometriosis
role in cell
- expression in
- growth
- phosphorylation in
- differentiation
- replication in
- survival
- cell cycle progression
- DNA damage response
- downregulation in
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ccnk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- cell division
- transcription from RNA polymerase II promoter
- response to DNA damage stimulus
- regulation of signal transduction
- positive regulation of transcription elongation, DNA-dependent
- regulation of cyclin-dependent protein kinase activity
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- positive transcription elongation factor complex b
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- RNA polymerase II carboxy-terminal domain kinase activity
- cyclin-dependent protein kinase activity