Lmtk2 Gene Summary [Mouse]
Predicted to enable myosin VI binding activity; protein phosphatase inhibitor activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including endosomal transport; protein phosphorylation; and transferrin transport. Predicted to act upstream of or within axon guidance and neurotrophin TRK receptor signaling pathway. Predicted to be located in several cellular components, including endosome; growth cone; and neuronal cell body. Is expressed in brain; olfactory cortex marginal layer; and pancreas. Orthologous to human LMTK2 (lemur tyrosine kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lmtk2 |
| Official Name | lemur tyrosine kinase 2 [Source:MGI Symbol;Acc:MGI:3036247] |
| Ensembl ID | ENSMUSG00000038970 |
| Bio databases IDs | |
| Aliases | lemur tyrosine kinase 2 |
| Synonyms | 2900041G10RIK, A330101P12, A330101P12Rik, AATYK2, BREK, cprk, hBREK, KPI-2, lemur tyrosine kinase 2, LMR2, PPP1R100 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lmtk2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- myosin binding
- protein serine/threonine kinase
- protein phosphatase inhibitor activity
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- protein-tyrosine kinase
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Lmtk2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- cancer
- prostatic carcinoma
- prostate cancer
- azoospermia
- non-insulin-dependent diabetes mellitus
- neuroticism
regulated by
- Exendin4
- streptozocin
- ciprofloxacin
- levodopa
- SIRT1
- Phe1 exendin
regulates
- TF
- TRK receptor
- L-threonine
- PPP1R2
- peptide
- YAP/TAZ
- receptor
role in cell
- guidance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- Golgi Apparatus
- growth cone
- recycling endosomes
- early endosomes
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lmtk2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transferrin transport
- early endosome to late endosome transport
- protein autophosphorylation
- protein phosphorylation
- peptidyl-serine phosphorylation
- peptidyl-threonine phosphorylation
- receptor recycling
- endocytic recycling
Cellular Component
Where in the cell the gene product is active
- growth cone
- early endosome
- perinuclear region of cytoplasm
- membrane
- recycling endosome
- Golgi apparatus
- neuronal cell body
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein phosphatase inhibitor activity
- protein binding
- myosin VI binding
- protein kinase activity
- protein serine/threonine kinase activity