Rheb Gene Summary [Mouse]
Enables GTP binding activity and protein kinase binding activity. Involved in negative regulation of cold-induced thermogenesis and positive regulation of TORC1 signaling. Acts upstream of or within positive regulation of oligodendrocyte differentiation and response to virus. Part of spliceosomal complex. Is active in Golgi membrane and synapse. Is expressed in chondrocranium bone; nervous system; nucleus pulposus; and sensory organ. Orthologous to human RHEB (Ras homolog, mTORC1 binding). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rheb |
| Official Name | Ras homolog enriched in brain [Source:MGI Symbol;Acc:MGI:97912] |
| Ensembl ID | ENSMUSG00000028945 |
| Bio databases IDs | |
| Aliases | Ras homolog enriched in brain |
| Synonyms | Ras homolog enriched in brain, Ras homolog, mTORC1 binding, RHEB1, RHEB2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rheb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding domain
- GTP binding domain-switch II region
- protein kinase binding
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- 50S ribosome-binding GTPase
- GTPase
- enzyme
- protein binding
- magnesium ion binding
- GTP binding domain-switch I domain
- prenylation site
- effector domain
- Ras subfamily of RAS small GTPases
- protein kinase activator
- GTP binding
- nucleotide-binding domain
- small GTP-binding protein domain
- GDP binding
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
- farnesylation site
Pathways
Biological processes and signaling networks where the Rheb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial neoplasia
- epithelial cancer
- cancer
- squamous cell cancer
- hepatitis B virus-related hepatocellular carcinoma
- liver cancer
- hemimegalencephaly
- seizures
- growth failure
role in cell
- expression in
- activation
- apoptosis
- proliferation
- accumulation in
- differentiation
- cell cycle progression
- phosphorylation in
- degeneration
- degeneration in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- endomembrane system
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- Golgi membrane
- lysosome membrane
- spliceosomes
- synapse
- perikaryon
- dendrites
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rheb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oligodendrocyte differentiation
- cellular response to nutrient levels
- small GTPase mediated signal transduction
- signal transduction
- regulation of type B pancreatic cell development
- regulation of macroautophagy
- regulation of cell cycle
- positive regulation of TOR signaling cascade
- positive regulation of oligodendrocyte differentiation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- postsynaptic density
- extracellular vesicular exosome
- membrane
- cytosol
- spliceosomal complex
- endomembrane system
- Golgi membrane
- lysosomal membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- GTP binding
- protein kinase binding
- protein serine/threonine kinase activator activity
- protein binding
- GTPase activity
- protein kinase activator activity
- GDP binding