Ppp1cb Gene Summary [Mouse]
Enables protein serine/threonine phosphatase activity. Involved in circadian regulation of gene expression; entrainment of circadian clock by photoperiod; and protein dephosphorylation. Located in cytoplasm. Is expressed in several structures, including brain; branchial arch; eye; and limb. Human ortholog(s) of this gene implicated in Noonan syndrome-like disorder with loose anagen hair 2. Orthologous to human PPP1CB (protein phosphatase 1 catalytic subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppp1cb |
| Official Name | protein phosphatase 1 catalytic subunit beta [Source:MGI Symbol;Acc:MGI:104871] |
| Ensembl ID | ENSMUSG00000014956 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1 catalytic subunit beta |
| Synonyms | 1200010B19, CS1 beta, CS1 β, Dis2m2, HEL-S-80p, MP, NSLH2, PP-1B, PP1beta, PP1c, PP1-C beta II, PP1-C β II, PP-1D, Pp1 delta, Pp1 β, Pp1 δ, PPP1beta, PPP1CD, PPP1C delta, PPP1C δ, protein phosphatase 1 catalytic subunit beta, protein PHOSPHATASE 1 CATALYTIC subunit, beta isoform, protein phosphatase 1 catalytic subunit β, protein PHOSPHATASE 1 CATALYTIC subunit, β isoform |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ppp1cb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Serine-threonine protein phosphatase N-terminal domain
- protein kinase binding
- myosin phosphatase
- catalytic domain
- phosphoprotein phosphatase
- protein serine/threonine phosphatase
- metallophosphatase superfamily, metallophosphatase domain
- protein binding
- MLCP
- Calcineurin-like phosphoesterase
- protein phosphatase
- phosphatase
- Protein phosphatase 2A homologues, catalytic domain
Pathways
Biological processes and signaling networks where the Ppp1cb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Cardiac β-adrenergic Signaling
- CCR3 Signaling in Eosinophils
- Cdc42 Signaling
- CDK5 Signaling
- Cellular Effects of Sildenafil (Viagra)
- Chemokine Signaling
- Dopamine Receptor Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- EIF2 Signaling
- ERK/MAPK Signaling
- Estrogen Receptor Signaling
- HIPPO signaling
- Insulin Receptor Signaling
- Integrin Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Regulation of Actin-based Motility by Rho
- RhoA Signaling
- Serotonin Receptor Signaling
- Synaptic Long Term Potentiation
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Huntington disease
- hereditary disorder
- Noonan spectrum disorder
- interstitial fibrosis
- Noonan syndrome-like disorder with loose anagen hair 2
- Noonan syndrome
- peripheral arterial disease
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
regulated by
- FSH
- dexamethasone
- Jurkat E6.1 cells
- beta-estradiol
- lipopolysaccharide
- FSHR
- budesonide
- BB0603
- regulatory T lymphocytes
- microcystin-LR
role in cell
- activation in
- expression in
- cell viability
- binding in
- survival
- phosphorylation in
- growth
- adhesion
- threonine phosphorylation in
- dephosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- postsynaptic density (PSD) fractions
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
- synaptosomes
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ppp1cb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- MAPK cascade
- circadian regulation of gene expression
- glycogen metabolic process
- protein dephosphorylation
- entrainment of circadian clock by photoperiod
- regulation of cell adhesion
- regulation of circadian rhythm
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nucleus
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- cytosol
- PTW/PP1 phosphatase complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- protein kinase binding
- protein binding
- metal ion binding
- phosphatase activity
- myosin-light-chain-phosphatase activity
- myosin phosphatase activity