Klc2 Gene Summary [Mouse]
Enables kinesin binding activity. Acts upstream of or within axo-dendritic transport. Located in ciliary rootlet; cytosol; and neuron projection. Part of kinesin complex. Used to study nonsyndromic deafness. Human ortholog(s) of this gene implicated in SPOAN syndrome. Orthologous to human KLC2 (kinesin light chain 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klc2 |
| Official Name | kinesin light chain 2 [Source:MGI Symbol;Acc:MGI:107953] |
| Ensembl ID | ENSMUSG00000024862 |
| Bio databases IDs | |
| Aliases | kinesin light chain 2 |
| Synonyms | 8030455F02RIK, kinesin light chain 2, Klc2 predicted, SPOAN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Klc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MalT-like TPR region
- type IV pilus biogenesis/stability protein PilW
- Tetratricopeptide repeats
- coiled-coil domain
- protein binding
- tetratricopeptide repeat
- kinesin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- spastic paraplegia, optic atrophy, and neuropathy
role in cell
- phosphorylation in
- expression in
- formation
- formation in
- survival
- localization
- quantity
- growth
- transport
- movement by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- Mitochondria
- cytosol
- ciliary rootlet
- nucleoplasm
- neurites
- perikaryon
- axons
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Klc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lysosome localization
- microtubule-based movement
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- kinesin I complex
- mitochondrion
- cytosol
- kinesin complex
- macromolecular complex
- lysosomal membrane
- plasma membrane
- nucleoplasm
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding
- kinesin binding