Zzz3 Gene Summary [Mouse]
Predicted to enable histone reader activity; lysine-acetylated histone binding activity; and methylated histone binding activity. Involved in regulation of cell cycle; regulation of cell division; and regulation of embryonic development. Part of ATAC complex. Is expressed in central nervous system and ureter. Orthologous to human ZZZ3 (zinc finger ZZ-type containing 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zzz3 |
| Official Name | zinc finger, ZZ domain containing 3 [Source:MGI Symbol;Acc:MGI:1920453] |
| Ensembl ID | ENSMUSG00000039068 |
| Bio databases IDs | |
| Aliases | zinc finger, ZZ domain containing 3 |
| Synonyms | 3110065C23RIK, 6430567E01RIK, ATAC1, DKFZp564I052, R75514, RGD1565468, zinc finger, ZZ domain containing 3, zinc finger ZZ-type containing 3, zinc finger, ZZ-type containing 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zzz3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ZZ
- SANT
- histone binding
- transcription regulator
- SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
- B-box-type zinc finger superfamily
- Myb-like DNA-binding domain
- protein binding activity, bridging
- UBR-box
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- insomnia
- lung adenocarcinoma
- lung carcinoma
- lung carcinoma process
- lung adenocarcinoma formation
regulates
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
- KAT2A
role in cell
- cell cycle progression
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zzz3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell division
- regulation of tubulin deacetylation
- regulation of embryonic development
- regulation of transcription, DNA-dependent
- regulation of cell cycle
- chromatin organization
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- mitotic spindle
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- protein binding
- methylated histone residue binding
- histone acetyl-lysine binding