Atp6v1g1 Gene Summary [Mouse]
Enables ATP hydrolysis activity and proton-transporting ATPase activity, rotational mechanism. Involved in synaptic vesicle lumen acidification. Located in cytosol; lysosomal membrane; and plasma membrane. Part of proton-transporting V-type ATPase, V1 domain and vacuolar proton-transporting V-type ATPase complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human ATP6V1G1 (ATPase H+ transporting V1 subunit G1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp6v1g1 |
| Official Name | ATPase, H+ transporting, lysosomal V1 subunit G1 [Source:MGI Symbol;Acc:MGI:1913540] |
| Ensembl ID | ENSMUSG00000039105 |
| Bio databases IDs | |
| Aliases | ATPase, H+ transporting, lysosomal V1 subunit G1 |
| Synonyms | 1810024D14Rik, ATP6G, ATP6G1, ATP6GL, ATP6J, Atp6v1g1 predicted, ATPase, H+ transporting, lysosomal V1 subunit G1, ATPase H+ transporting V1 subunit G1, Atp synthase g1, VAG1, V-ATPase V1-G1, Vma10 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atp6v1g1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Vacuolar (H+)-ATPase G subunit
- ATPase binding
- vacuolar ATP synthase, subunit G
- H+-transporting two-sector ATPase
- hydrogen-transporting ATPase activity, rotational mechanism
- protein binding
- ATPase
- transporter
Pathways
Biological processes and signaling networks where the Atp6v1g1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- ATP6V1G1
- iron ion
role in cell
- acidification
- replication in
- acidification in
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- detergent resistant lipid raft fraction
- intracellular space
- somatodendritic region
- cellular membrane
- Plasma Membrane
- cytosol
- lysosome membrane
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atp6v1g1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular iron ion homeostasis
- regulation of macroautophagy
Cellular Component
Where in the cell the gene product is active
- vacuolar proton-transporting V-type ATPase, V1 domain
- extracellular vesicular exosome
- cytosol
- synaptic vesicle membrane
- lysosomal membrane
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- protein binding
- proton-transporting ATPase activity, rotational mechanism
- ATPase binding