Mia3 Gene Summary [Mouse]
Predicted to enable cargo receptor activity. Acts upstream of or within chondrocyte development; collagen fibril organization; and positive regulation of bone mineralization. Located in endoplasmic reticulum membrane. Is expressed in several structures, including branchial arch; embryo mesenchyme; heart; nervous system; and nose. Orthologous to human MIA3 (MIA SH3 domain ER export factor 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mia3 |
| Official Name | melanoma inhibitory activity 3 [Source:MGI Symbol;Acc:MGI:2443183] |
| Ensembl ID | ENSMUSG00000056050 |
| Bio databases IDs | |
| Aliases | melanoma inhibitory activity 3 |
| Synonyms | 9130229H14RIK, A930039G15Rik, ARNT, B230399H06Rik, C129 reactive peptide, D320, FLJ39207, Gm1525, MIA SH3 domain ER export factor 3, ODCD2, TANGO, TANGO1, UNQ6077 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mia3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Formin Homology Region 1
- Mitotic checkpoint protein
- TPR/MLP1/MLP2-like protein
- cargo receptor activity
- F-type ATP synthase, membrane subunit b
- SWI5-dependent HO expression protein 3
- coiled-coil domain
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- proline rich domain
- Src Homology 3 domain superfamily
- C-terminal coiled-coil domain found in the laminin subunit beta (LAMB) family
- Leucine zipper
- ClyA-like
- HOOK protein coiled-coil region
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heart disease
- coronary artery disease
- myocardial infarction
- odontochondrodysplasia with hearing loss and diabetes
- ondontochondrodysplasia 2 with hearing loss and diabetes
- dwarfism
- heart failure
- angina pectoris
role in cell
- number
- adhesion
- migration
- exocytosis by
- accumulation in
- development
- organization
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- endoplasmic reticulum exit sites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mia3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell adhesion
- protein transport
- cargo loading into COPII-coated vesicle
- cell migration involved in sprouting angiogenesis
- endoplasmic reticulum organization
- exocytosis
- protein secretion
- lipoprotein transport
- positive regulation of leukocyte migration
- ER to Golgi vesicle-mediated transport
- wound healing
- cargo loading into vesicle
- protein localization to endoplasmic reticulum exit site
- negative regulation of lymphocyte migration
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- intracellular membrane-bounded organelle
- membrane
- endoplasmic reticulum exit site
Molecular Function
What the gene product does at the molecular level
- protein binding
- cargo receptor activity