Ryk Gene Summary [Mouse]
Enables Wnt receptor activity; Wnt-protein binding activity; and frizzled binding activity. Involved in Wnt signaling pathway and nervous system development. Acts upstream of or within several processes, including commissural neuron axon guidance; negative chemotaxis; and negative regulation of axon extension involved in axon guidance. Located in cytoplasm; nucleus; and plasma membrane. Is active in glutamatergic synapse; postsynaptic density membrane; and presynaptic active zone membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human RYK (receptor like tyrosine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ryk |
| Official Name | receptor-like tyrosine kinase [Source:MGI Symbol;Acc:MGI:101766] |
| Ensembl ID | ENSMUSG00000032547 |
| Bio databases IDs | |
| Aliases | receptor-like tyrosine kinase |
| Synonyms | D3S3195, DERAILED, ERK-3, Etk3, JTK5, JTK5A, Nyk-R, receptor-like tyrosine kinase, RYK1, Vik |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ryk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Wnt-protein binding
- Protein kinase (unclassified specificity)
- frizzled binding
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- Wnt receptor
- protein binding
- protein-tyrosine kinase
- Protein kinase domain
- WIF domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- transmembrane domain
- intracellular domain
- Tyrosine kinase, catalytic domain
- transmembrane receptor
- coreceptor
Pathways
Biological processes and signaling networks where the Ryk gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- mechanical hypersensitivity
- vascular dementia
- hypoplasia
- essential hypertension
- cleft palate syndrome
- venous thromboembolism
- major depression
role in cell
- expression in
- growth
- proliferation
- tumorigenicity
- development
- differentiation
- morphogenesis
- sprouting
- transcription in
- guidance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- reticular fibers
- cellular membrane
- Nucleus
- presynaptic membrane
- synaptic membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ryk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron differentiation
- signal transduction
- neuron projection development
- multicellular organismal development
- axon guidance
- transmembrane receptor protein tyrosine kinase signaling pathway
- neurogenesis
- negative regulation of axon extension involved in axon guidance
- positive regulation of MAPK cascade
- protein phosphorylation
- skeletal system morphogenesis
- corpus callosum development
- axon extension involved in axon guidance
- synapse assembly
- axonogenesis
- canonical Wnt receptor signaling pathway
- positive regulation of kinase activity
- Wnt receptor signaling pathway, planar cell polarity pathway
- non-canonical Wnt receptor signaling pathway
- commissural neuron axon guidance
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- ATP binding
- protein tyrosine kinase activity
- frizzled binding
- Wnt-activated receptor activity
- protein binding
- transmembrane signaling receptor activity
- transmembrane receptor protein tyrosine kinase activity
- Wnt-protein binding